COVID-19 vaccines

Last modified

March 3, 2021 @ 18:21 PM

The first vaccines against COVID-19 were approved in December 2020. Further COVID-19 vaccines have since been approved and many others are in development

As COVID-19 is a relatively new disease, and the first COVID-19 vaccines were introduced in late 2020, you may have some questions you would like answered prior to having the vaccine. 

A number of agencies and health authorities – including the European Medicines Agency, the World Health Organization, the Children’s Hospital of Philadelphia, the British Society for Immunology, and Immunise BC – have developed answers to frequently asked questions about COVID-19 vaccines. 

Here, we summarise some of the most common issues raised, along with comments we’ve picked up from our social media channels. If there is a question you would like us to add, contact us. We focus below on vaccine development and technologies, as well as safety and efficacy. For information about vaccine delivery in your area, contact local health authorities. 

How were COVID-19 vaccines developed within one year?

It usually takes several years to develop a vaccine. The successful development of COVID-19 vaccines is down to foresight, hard work and good luck. Given the urgency of containing a global pandemic, unprecedented resources were directed at vaccine development. 

Crucially, clinical trials were streamlined without compromising on safety. Tens of thousands of people volunteered to take part in trials, phases of trials were overlapped rather than being conducted consecutively, and regulators began ‘rolling reviews’ while trials were ongoing. 

At the same time, even before vaccines were independently approved by regulators, governments placed advance orders for vaccines and companies began manufacturing. This meant that when regulators were satisfied that vaccines were safe and effective, millions of doses could be shipped around the world. 

Do COVID-19 vaccines work?

Yes. In clinical trials, the vaccines now approved for use have been shown to prevent COVID-19 in most people. Precise results from clinical trials vary from vaccine to vaccine, but published data indicate a strong reduction in disease among people who have been vaccinated.

Are COVID-19 vaccines safe?

The short answer is ‘Yes’. COVID-19 vaccines have been approved by independent regulators following clinical trials on tens of thousands of people. Since their authorisation, tens of millions of people have had COVID-19 vaccines. 

The most common side effects of approved COVID-19 vaccines are fatigue, headache and muscle aches. These local effects are short-lived and are expected. In a small number of individuals, allergic reactions have been recorded. Speak to your health professional if you have a history of allergic reactions. 

What about long-term effects?

As COVID-19 is a new disease, and COVID-19 vaccines are new, it is not scientifically possible to know the long-term impact of the disease or the vaccines.

How many doses do I need?

Vaccines currently available are approved for a two-dose regimen. Data from trials suggests that a strong response is generally seen 7-10 days after the first dose in most people. 

The typical gap between doses is three to four weeks; some countries are spacing out the two doses to increase the number of people who can benefit from the vaccine during the early high-demand phase of the vaccine rollout. Your health professional/health authorities will advise on when you should return for a second dose. 

Single-dose vaccines are also in development. 

Will the vaccine prevent transmission of the disease?

In short, we don’t know yet. The clinical trials for approved COVID-19 vaccines tested whether vaccines prevented disease (which they did). Some experts have expressed confidence that the vaccines will prevent – or at least reduce – the spread of disease. However, it will take time to collect data to answer this question with certainty. For a more detailed look at the science behind this question, try here.

What are mRNA vaccines?

Some of the earliest vaccines approved for use against COVID-19 use mRNA technology. These vaccines contain a short piece of messenger RNA (mRNA) – a string of genetic instructions. Like a recipe, these instructions tell the body to make a specific, single protein from the virus (and not the whole virus). This ‘spike protein’ is on the surface of the SARS-CoV-2 virus, and is the part of the body that our immune system needs to learn to recognise. These are the characteristic spikes that you may have seen in images showing the surface of the virus. 

When the body has made these proteins, the immune system destroys them and remembers them if the virus enters the body in future, like what happens in natural infection against COVID-19. The mRNA from the vaccine breaks down quickly and disappears .

What are the other types of vaccines that have been approved?

Whereas mRNA vaccines deliver mRNA for the spike protein wrapped up in tiny parcels of ‘fat’, other vaccines use a slightly different approach to achieve the same result. A vaccine developed at Oxford University, now available across Europe, delivers the genetic code for the SARS-CoV-2 spike protein to the body by inserting it into another virus. This virus cannot replicate, making it harmless. Once inside the body, it triggers an immune response. 

Who are COVID-19 vaccines for?

Available COVID-19 vaccines have primarily been tested on adults.

What about children?

While many vaccine-preventable diseases affect children, it appears young people are at the lowest risk of being severely affected by COVID-19. Children are usually included in clinical trials for RSV or meningitis vaccines, for example. For COVID-19, the priority has been to protect adults. Trials focused on adults of all ages and vaccines were approved on that basis.

Can pregnant women have COVID-19 vaccines?

Pregnant women were not recruited for initial trials on COVID-19 vaccines. As a result, vaccines were initially not recommended during pregnancy, except where the individual is at high risk of COVID-19.

However, the WHO has published advice saying that pregnant women can have COVID-19 vaccines. The UK medicines regulator has raised no concerns for safety in pregnancy. Authorities in Ireland say pregnant women offered the vaccine should have it.

Over time, data will be collected on the safety of vaccinating women who did not know they were pregnant at the time of vaccination. This will give a fuller picture of the safety of COVID-19 vaccines during pregnancy. 

Vaccination during pregnancy is common for some diseases. For example, flu vaccine and pertussis are recommended during pregnancy. However, ‘live’ vaccines are not advised during pregnancy.

How long will immunity last?

This is not yet clear: nobody has had COVID-19 – nor the COVID-19 vaccine – for much longer than a year. Over time, it will become clear whether booster vaccines would be necessary to maintain protection. There are some signs that people who had SARS (which is a coronavirus) in 2003 still show some immunity. This may give reason to hope that natural and vaccine-induced immunity against COVID-19 will be long-lasting. Time will tell.